DNA/RNA Origami Core Facility

The DNA/RNA Origami Core Facility at the Center for Molecular Biology of Heidelberg University (ZMBH) supports research groups in and around the Neuenheimer Feld campus in the design and production of DNA origami nanostructures. It provides specialized expertise as well as the necessary infrastructure.

DNA and RNA origami technology enables the programmable construction of nanoscale structures from nucleic acids. Through computer-aided design, defined two- and three-dimensional nanostructures can be designed and produced with high precision. This technology is increasingly being applied in various research areas, including fundamental biophysical research, nanomedicine, and the development of synthetic biomolecular systems.
The DNA/RNA Origami Core Facility supports researchers in planning and implementing projects in the field of nucleic acid nanotechnology. Its services include consultation on structural design and computer-aided modeling, assistance with the assembly and optimization of origami structures, as well as guidance in their experimental analysis and application.

In addition, the facility teaches fundamental methods and workflows of DNA and RNA origami technology, including design strategies, folding and purification protocols, and basic characterization methods. After appropriate training, certain tasks can be carried out within the facility in close collaboration with the Core Facility team.

The facility provides infrastructure and expertise for the planning, production, and analysis of DNA/RNA origami structures and supports interdisciplinary research projects across the life and materials sciences.

For initial contact, please send a brief description of your project by email to: k.sachenbacher(at)zmbh.uni-heidelberg.de

Our services:
Design of DNA/RNA origami nanostructures
Support in the assembly of DNA/RNA origami nanostructures
Support in experimental data analysis
Support in the characterization of DNA/RNA origami nanostructures